In the draft, the Bills focused on defense, selecting CB Max Hairston (first round), DT TJ Sanders (second), Edge Landon Jackson (third), DT Deone Walker (fourth), CB Jordan Hancock (fifth), TE Jackson Hawes (fifth) and cornerback Dorian Strong (sixth ).

The wide receiver position continues to be a hot-button conversation among fans of the Buffalo Bills, especially after the team failed to make a significant investment in the position during the 2025 NFL Draft.

The Buffalo Bills entered the 2025 NFL Draft with 10 selections, and came away with nine players. For a minute, it looked as if the Bills had forgotten that the offense exists. Buffalo used its first five picks to draft defensive players. In the end, six of the nine draftees are on defense (3 CB, 2 DT, 1 DE).

Bills general manager Brandon Beane began a Monday morning radio appearance with a strong response to criticism against the team's approach to the wide receiver position.