No. 6 BYU is the classic risky pick to make a deep run that could win you your bracket pool or lose it for you on Day 1.

It's the first time in school history that the Bruins are the top team in the tournament. They had two losses on the season, both of which came to the Trojans.

From the run on SEC squads to power-conference teams looking for a breakthrough to the players you need to know, here is a primer on March Madness.